As among 15 analytes, levels of ApoA2, ApoA4, Ddimer, HE4, and LRG 1 were found to be altered in patients with both early and advanced CRC stages (Figure 1), diagnostic performance of the combination of these 5 biomarkers was additionally evaluated and was shown to be comparable to that of the full 15-biomarker models (Table S5). This evidence concerns the gene APOA4 and colorectal carcinoma.