IL31 and neoplasm: We also detected the migratory and invasive capacity of these clones with or without IL-31 treatment; similar results were observed that IL-31 induced the migration (Figure 4B) and invasion (Figure 4C) of control MDA-MB-231 cells, however, it completely lost the ability in IL31RA-silencing cells, indicating that IL-31 is able to promote BLBC tumor progression and its pro-oncogenic functions are strongly dependent on IL31RA.