ABCC1 and acute lymphoblastic leukemia: In accordance, the binding of α2:β1 integrin to collagen I has been shown to promote resistance to doxorubicine in Jurkat T-ALL cells by activating ERK and maintaining high levels of the anti-apoptotic Bcl-2 protein Mcl-1 (46) or upregulating ABCC1/MRP-1 (47).