BRAF and neoplasm: Despite data suggesting immunotherapy after BRAF inhibitor (BRAFi) therapy is associated with a lower response rate (8, 9), there are data suggesting that early treatment changes with BRAFi may actually improve antitumor immune responses (10, 11) and expression of tumor antigens (12) suggesting a cooperative interplay between initial BRAFi-induced changes and intratumoral immune activation (13, 14).