Overall, the above data suggests the following working model of how modulation of CD11b activity regulates tumor growth (Figure 11); Lung tumors, via upregulation of CCL2, recruit Ly6ChiCD11b+ myeloid cells, which get polarized to an M2- like state in the TME, resulting in increased M2/M1 TAM ratio in the TME in a feed-forward loop. The gene discussed is ITGAM; the disease is neoplasm.