Furthermore, immunofluorescence-based analyses of the tumor tissues also showed a significant decrease in F4/80+CD206+ M2-polarized macrophages (Figures 4I,J) as well as a significant increase in F4/80+MHCII+ M1-polarized macrophages (Figures 4K,L) in LLC tumors from CD11b KI mice, as compared to tumors from the WT animals. The gene discussed is MRC1; the disease is neoplasm.