Most relevant molecular drivers that participate to melanoma metabolic plasticity include AKT, BRAF, p14ARF, MYC, NRAS, phosphatidylinositol-4,5-bisphosphate 3 kinase catalytic subunit α (PIK3CA) and phosphatase and tensin homolog (PTEN) (14–20). The gene discussed is PTEN; the disease is melanoma.