The binding of the urokinase plasminogen activator (uPA) to its receptor uPAR, expressed in one-third of melanomas (120), sustains the expression of the extracellular matrix metalloproteinases inducer (EMPPRIN) and of ENO1, which both connect lactate homeostasis and glycolysis with the invasive phenotype of melanoma cells (119). The gene discussed is ENO1; the disease is melanoma.