Of the ten hub genes, the Kaplan–Meier analyses suggested that the lower expression level of CSTA was significantly associated with worse OS of the HNSCC patients (P < 0.05) (Figure 8D), while with DFS there was no significant difference observed in HNSCC patients with an expression level of CSTA (P < 0.05) (Figure 9D). The gene discussed is CSTA; the disease is head and neck squamous cell carcinoma.