While TET1 was ectopically expressed by ~35-fold in the TET1-CD overexpression T24 cells, several previously identified TET1 target genes, such as TIMP3 and DKK1 in other cancer types (13, 14), were also induced at 2.1- and 1.8-fold compared to the control cells (EV), respectively. The gene discussed is TIMP3; the disease is cancer.