Particularly, the expression levels of SIRT7 were significantly positively correlated with seven gene markers in breast cancer-luminal (Table 2), such as CD19 (r = 0.105, p = 1.46e-02), IRF5 (r = 0.165, p = 1.13e-04), KIR2DL1 (r = 0.106, p = 1.31e-02), T-bet (r = 0.103, p = 1.00e-02), FOXP3 (r = 0.12, p = 5.06e-03), PD1 (r = 0.134, p =1.74e-03), and GZMB (r = 0.108, p = 1.14e-02). The gene discussed is IRF5; the disease is breast carcinoma.