In an early study by Pathmanathan et al. (20), both EBV latent gene products (e.g., EBERs and LMP1) and homogeneous lengths of TR repeats were detected in NPC and precancerous lesions, suggesting that the clonal latent EBV infection is a crucial event in the initiation of this virus-associated cancer (20). This evidence concerns the gene PDLIM7 and nasopharyngeal carcinoma.