If 1,25(OH)2D3-VDR signaling through the putative VDRE in the European-derived DRB1 *1501 allele were to increase DNA methylation and reduce its expression in MS patient CD4+ T cells, then one could suggest that these epigenetic marks are dynamic in post-natal life rather than fixed in gestation, which is critically important information for MS prevention efforts. The gene discussed is CD4; the disease is myeloid sarcoma.