Specifically, elevated acetylation of BECLIN1 reduced autophagosome maturation in cancer cells26, increased deacetylation of LC3 promoted autophagy following caloric restriction27 and SIRT1 deacetylation of LC3 has been shown to effectively redistribute LC3 in an activated form from nucleus to cytoplasm controlling total LC3 levels28,29. The gene discussed is SIRT1; the disease is cancer.