PRRT2 and leukemia: PKCβII is known to bind to and be activated by PG to trigger cell cycle progression in human leukemia cells [8], However, although multiple PKC isozymes have been identified in keratinocytes, there has been some debate regarding the presence of PKCβ in these cells [16 – 19], with an initial report failing to detect PKCβ in mouse keratinocytes using northern analysis [16].