Two-hundred and seventy-eight individuals with type 1 diabetes (clinically defined as requiring insulin within 6 months of diagnosis), 319 with type 2 diabetes (clinically defined as not requiring insulin within 6 months of diagnosis), and 594 probands with a genetic diagnosis of MODY (243 GCK, 296 HNF1A, and 55 HNF4A) have been compared regarding simple and widely available clinical variables [21]. The gene discussed is INS; the disease is type 1 diabetes mellitus.