Furthermore, several pathways were provided to be colon cancer-related pathways, such as wnt pathway, PI3K-AKT signaling pathway and cell cycle signaling pathway were reported as common oncogenic signaling pathways (Sanchez-Vega et al., 2018), which could be regulated by PSMA1 (degree = 54), MRAS (degree = 10), and LEP (degree = 10), respectively. The gene discussed is LEP; the disease is malignant colon neoplasm.