Furthermore, by screening through the criteria of the PPI network, cancer-related pathway and TRS modeling, essential features with gene symbols of EPB41, PSMA1, FGFR3, MRAS, LEP, C7orf46, LOC285000, LBP, ZNF35, SLC30A3, LECT2, RNF7, and DYNC1I1 were identified as PRBs for COAD patients. The gene discussed is LEP; the disease is colon adenocarcinoma.