The high fold increase in the mRNA expression in nearly all resistant tumor along with few sensitive samples clearly suggest that high expression of MDR1 gene is not due to the specific chemotherapeutic drug as these tumor samples were resistant to either a combination of Paclitaxel and Carboplatin (CB/TX) or Carboplatin alone or Fluorouracil (5FU). This evidence concerns the gene ABCB1 and neoplasm.