PGP and neoplasm: Several in vitro and in vivo studies have confirmed that P-gp/MDR1expression is the highest in tumor derived tissues as compared to normal tissues and also as multidrug resistant cancer cells which produce larger extracellular vesicles (EVs) than their sensitive cellular counterparts (Baekelandt et al., 2000; Yusuf et al., 2003; Lopes-Rodrigues et al., 2016).