CDH1 and neoplasm: In contrast, E-cadherin, which belongs to the Ca2+ dependent cell adhesion molecule family (Guilford et al., 1998), regulates cell-cell adhesions, mobility, and proliferation of epithelial cells and is a potent invasive suppressor for tumor cells (Ma et al., 2010; Satow et al., 2014; Indra et al., 2018).