KRAS and colorectal carcinoma: Therefore, preliminary association analysis of MICA codon 295 polymorphisms and alleles to driver gene mutations, specifically KRAS codon 12 mutation, in CRC samples indicated that MICA ∗012:01 was significantly associated with an increased OR for KRAS codon 12 mutation (p = 0.027, OR = 3.33, Table 2).