MICA and colorectal carcinoma: However, it is worth noting that MICA codon 295 polymorphism ∗A5.1 results in a premature stop codon that leads to a break in TM region of MICA to produce a soluble MICA (sMICA) (Zhou et al., 2014) that interacts with NKG2D, resulting in NKG2D internalization and subsequent suppression or impairment of NKG2D-mediated immune response (Groh et al., 2002) that may alter susceptibility to CRC development.