Overexpression of MICA ∗012:01 allele enhanced the malignant phenotype of CRC with KRAS mutation specifically proliferation, invasion, and metastasis in cultured CRC cell line which may suggest that MICA ∗012:01 enhances the metastatic potential of CRC by interacting with the NKG2D to evade immune surveillance. Here, KRAS is linked to colorectal carcinoma.