We conducted further association studies of MICA codon 295 polymorphisms and MICA alleles with tumor characteristics such as differential status, UICC stage, tumor size, invasion depth, lymph nodes metastasis, and gross classification, and discovered that A5.1 was significantly increased in highly differentiated CRC compared to that in medium state (p = 0.019; Supplementary Table S4). The gene discussed is MICA; the disease is neoplasm.