For example, the transcription factor KLF15 (Krüppel-like factor 15) had been proven to be higher in tumor tissue than that of adjacent non-tumor tissue and played an important role in promoting proliferation and carcinoma diversification in lung adenocarcinoma, associated with poor prognostic outcome (Gao et al., 2017). The gene discussed is KLF15; the disease is lung adenocarcinoma.