AGO1 and infection: RISCs that include AGO1, 2, 3, 4, 5, and 9 can bind to virus sRNA and Arabidopsis AGO5 can bind potato virus X (PVX) sRNA in N. tabacum and suppress the infection thereof, but only in the presence of an intact AGO2 interaction (Brosseau and Moffett, 2015).