In human primary keratinocytes, miRNA155 suppressor, rosmarinic acid (RA), cycloastragenol (CAG), and the effective part of Datura metel L. (EPD) have been shown to inhibit NLRP3-induced inflammatory cytokines such as IL-1β, IL-6, IL-8, CCL20, and TNF, indicating that they are therapeutic candidates for psoriasis treatment (89, 93, 95, 96). This evidence concerns the gene NLRP3 and psoriasis.