PRF1 and metabolic dysfunction-associated steatotic liver disease: These data are seemingly in contrast to a recent paper published by Cuff et al. which showed that after 24 weeks of obesogenic diet [22.6% fat, 23.0% protein, and 40.2% carbohydrate (w/w) supplement with sweetened condensed milk (Nestle) ad libitum], there was no difference in hepatomegaly and liver weight between the wild-type and perforin knockout female mice; otherwise, the fibrosis was significantly lower, and perforin KO mice suffer from less severe NAFLD mediated by NK cells (37).