CALCA and cystic fibrosis: Treatment with RvD1 significantly reduced KC (a major PMN chemoattractant and the murine analog of IL-8) and IL-17 (a cytokine involved in CF lung pathology) in lung homogenates of CF mice, both at 5 and 21 DPI, whereas IL-12 and IL-6 were significantly lower in RvD1-treated animals at 5 DPI (Figure 3A).