The pro-resolving protein annexin A1 is downregulated in nasal epithelial cells (30), and concentrations of lipoxin A4 are reduced in bronchoalveolar lavage fluid (BALF) of patients with CF (31, 32), possibly because of a CFTR-mediated reduction in their biosynthesis (33), and ratios of sputum concentrations of RvD1 to interleukin (IL)-8 are diminished in individuals with CF (34). The gene discussed is CFTR; the disease is cystic fibrosis.