Here, we found that RvD1 regulated transcriptomics and signaling in MΦ and epithelial cells of patients with CF exposed to P. aeruginosa, reducing genes and proteins related to the NF-κB signaling pathway that drive leukocyte chemotaxis, activation, and cytokine release (Figures 6, 7). Here, NFKB1 is linked to cystic fibrosis.