The study was continued and pituispheres were cultured in sphere promoting media, collected for WGA, and exome sequencing and analyzed together with a corresponding formalin-fixed paraffin-embedded (FFPE) adenoma tissue samples for stem/progenitor and pituitary lineage-specific commitment cell markers such as SOX2, CD15, GFRα2, nestin, Pit-1, SF-1, and Tpit (Table 2). Here, SOX2 is linked to adenoma.