It should be noted that P2X7 receptors are expressed by different types of pancreatic cells such as alpha and beta cells, and multiple evidence corroborates the regulatory action exerted by the P2X7 on pancreatic stellate cell proliferation, insulin secretion, and involvement in type 2 diabetes pathogenesis (69–71). The gene discussed is P2RX7; the disease is type 2 diabetes mellitus.