SGPL1 and amyotrophic lateral sclerosis: The sharp increase in the expression of S1P lyase (S1PL) at the early stage of ALS is responsible for a decrease in anti-apoptotic reserves of motor neuron cells and the rapid development of apoptosis at the terminal stage of these disease of ALS, because S1PL degradates S1P that protects cells from apoptosis to the final products ethanolamine phosphate and hexadecenal.