GNRH1 and Infertility: When exploring pre-post changes in depressive symptoms, effect sizes suggested mild mood worsenings for most protocols (effect sizes ≤ -0.4), with the following pattern (worse to better): GnRH agonist > GnRH antagonist > no gonadotropin stimulation.<h4>Conclusions</h4>This is the first systematic review exploring the psychopathological effects of hormonal infertility treatments.