Besides, the evidence suggests that IL-1β knock-down in the hippocampus can significantly alleviate the memory deficits and anxiety and depression-like behavior of the mice induced by lipopolysaccharide(LPS) may due to eliminates the down-regulation of LPS-induced neuropeptide(VGF) and brain-derived neurotrophic factor(BDNF) (81). This evidence concerns the gene BDNF and depressive disorder.