First, they confirmed that SS causes a severe inflammatory response not only in circulation but also in the brain, leading to severe brain damage, they found that some inflammatory biomarkers (TLR-2, TLR-4, MYD88, IL-1β, TNF-α, NF-κB, and MMP-9) were significantly higher in cerebrospinal fluid from SS animals than control group, and the anomalies of these molecules in circulatory levels and in brain tissue as well as in CSF were observably inhibited by adipose-derived mesenchymal stem cell-derived exosomes (83). This evidence concerns the gene TLR4 and synovial sarcoma.