Whereas, a research manifested that Olig2 expression was decreased while LINGO-1 expression for the animal model with spontaneous recurrent epileptic seizures combined depression (SRS-D), and compared to normal group, Olig2 and LINGO-1 expression was no significant difference in the animal model with spontaneous recurrent epileptic seizures combined no depression (SRS-ND) (67). This evidence concerns the gene LINGO1 and Seizure.