For instance, PINK1/Parkin-mediated mitophagy is activated during pressure-overload (Billia et al., 2011; Shirakabe et al., 2016), following myocardial infarction (MI) (Kubli et al., 2013), and in I/R (Siddall et al., 2013). The gene discussed is PINK1; the disease is myocardial infarction.