For instance, PINK1/Parkin-mediated mitophagy is activated during pressure-overload (Billia et al., 2011; Shirakabe et al., 2016), following myocardial infarction (MI) (Kubli et al., 2013), and in I/R (Siddall et al., 2013). Here, PRKN is linked to myocardial infarction.