Our previous study reported that CathD was significantly up-regulated in MPTP-induced PD mice in vivo and in LPS-induced mice primary microglia in vitro, and that knockdown of CathD inhibited neuroinflammation and protected DA neurons from microglia-mediated neurotoxicity via inhibiting the activation of NF-κB signaling pathway (Gan et al., 2018). Here, NFKB1 is linked to Parkinson disease.