After LBP intervention, the protein expression levels of GRP78, p-eIF2α, and CHOP were found to be significantly lower in the testicular tissues of the treated mice as compared to that in the obese mice, indicating that LBP could down-regulate the expression of GRP78, p-eIF2α, and CHOP, thus inhibiting ERS, and anti-male infertility caused by obesity. This evidence concerns the gene HSPA5 and Obesity.