In patients with previously untreated metastatic nonsquamous NSCLC without EGFR or ALK mutations, the addition of pembrolizumab to standard chemotherapy of pemetrexed and a platinum-based drug resulted in significantly longer OS and PFS than chemotherapy alone (Clinical Trials: NCT02578680) (Gandhi et al., 2018). The gene discussed is ALK; the disease is non-small cell lung carcinoma.