ALK and non-small cell lung carcinoma: To assess the efficacy and safety of atezolizumab plus chemotherapy versus chemotherapy alone as first-line therapy for non-squamous NSCLC, IMpower130 showed a significant and clinically meaningful improvement in OS and a significant improvement in PFS with atezolizumab plus chemotherapy, than chemotherapy as first-line treatment of patients with stage IV non-squamous NSCLC and no ALK or EGFR mutations.