CASP3 and neoplasm: Live imaging of the spheroids (Figure 6D, Video S1) revealed that the stellate cells were not affected by the presence of the constructs, but the apoptosis induction was fast and intense in the tumor cells, measured as green fluorescence originated by cleavage of caspase 3/7 substrate, with apoptosis already observed 12 h after the start of treatment (Figure 6E).