To test the possibility that this was due to microglial sensitization in the vicinity of Aβ plaques, we also carried out IL-4 injections in the striatum, which does not accumulate extracellular Aβ plaques in the 3xTg AD mouse and quantified the number of arginase-1 positive cells (Supplementary Figure 1). This evidence concerns the gene ARG1 and Alzheimer disease.