CYP1B1 and age-related macular degeneration: Many of the CCT-associated loci identified in this study, are also associated with other eye conditions, particularly NPLOC4, CYP1B1, RBMS3, and PLEKHA1. NPLOC4 encodes the NPL4 homolog, ubiquitin recognition factor, and polymorphisms at this locus have been previously reported to be associated with myopia, age-related macular degeneration, eye color, and recently with corneal or refractive astigmatisms, strabismus and macular thickness48–53.