Moreover, ICAM3, CCL16, PDE3A, PRTN3, TRAF6, BCAR1, IL-1α, IL-1β, NFκB1, SOX2 and OCT4 decreases the protein expression as indicated by immunofluorescence staining in the ibuprofen-treated MDA-MB-231 breast cancer cells versus the control (Fig. 3d). Here, TRAF6 is linked to breast cancer.