BIK and cancer: BIK-LTC-250 cell lines derived from both MCF-7 and MDA-MB-231 cells had ~1.7 times increased numbers of mammosphere colonies than their control EV-LTC-250 or BIK-LTC-0 cell lines, indicating that BIK-treatment increased the proportion of cancer stem-like cells (Fig. 5d and Supplementary Fig. 10B).