AKT1 and neoplasm: Furthermore, a study on the tumor microenvironment of NSCLC demonstrated that the activation of the IGF1Rβ/PI3K/AKT pathway by hypoxia could induce EMT, which might subsequently enhance radioresistance.51 Consequently, we inferred that in NSCLC cells, radioresistance with enhanced DNA damage repair might be promoted by the miR-410-induced EMT process.