Overexpression of all the ISGs, except for MAP3K5 and IFI6 whose expression was cytotoxic in HUVEC VP30 cells, significantly reduced EBOV-driven luciferase expression at three days post infection (Supplementary Fig. 3b) in a similar manner of inhibition to that observed in HEK-293T VP30 (Fig. 1b). This evidence concerns the gene IFI6 and infection.