PKM and central nervous system cancer: Phenotypes induced by depleting SNHG14 (decreased the expression of PKM2 and GLUT1; inhibition of glycolysis and glycolytic capacity, lactate production and glucose uptake; suppression of proliferation; enhanced apoptosis) could be reversed by silencing IRF6 in glioma cells (Fig. 6a–d, Supplementary Fig. S4j, k).