Taken together, our findings demonstrate that SBS, consisting of SNHG14, STAU1 and specific sequence in the 3′ UTR of IRF6, is crucial in SNHG14-regulated degradation of IRF6 mRNA; SNHG14 promotes the degradation of IRF6 mRNA via the SMD pathway, thereby enhancing aerobic glycolysis and cell proliferation in glioma. This evidence concerns the gene SNHG14 and central nervous system cancer.