Taken together, our findings demonstrate that SBS, consisting of SNHG14, STAU1 and specific sequence in the 3′ UTR of IRF6, is crucial in SNHG14-regulated degradation of IRF6 mRNA; SNHG14 promotes the degradation of IRF6 mRNA via the SMD pathway, thereby enhancing aerobic glycolysis and cell proliferation in glioma. Here, IRF6 is linked to central nervous system cancer.