To investigate the effect of core exosome disruption on the p53-dependent signalling pathway in more detail and on a protein level, HCT116 cells (a human colorectal cancer cell line) were treated with a siRNA targeting the EXOSC8 or EXOSC9 mRNA or a control siRNA targeting firefly luciferase. The gene discussed is EXOSC8; the disease is colorectal cancer.