Furthermore, a significantly close relationship between IL-6 levels in critical COVID-19 patients with fatal outcome (64.0 pg/ml, IQR 25.6–111.9) and RNAemia was found, in particular, the 83.3% of patients with IL-6 > 100 pg/ml had positive levels of RNAemia, r 0.902. This evidence concerns the gene IL6 and COVID-19.