Short sleep duration, smoking status, television watching, obesity, high systolic blood pressure, low grip strength, depressive symptoms, low HDL cholesterol, glycated haemoglobin, cystatin C, and gamma-glutamyltransferase concentrations were significantly associated with a higher risk of CVD after adjusting for child maltreatment, sociodemographic characteristics, and other potential mediators. This evidence concerns the gene CST3 and obesity due to melanocortin 4 receptor deficiency.