In prostate cancer, some advances in this field were also achieved, with Karlsson and colleagues finding that TRAMP-C1-EVs impaired osteoclastogenesis [210] and Inder et al. showing that Cavin-1/PTRF can alter the EV content of PC, which modifies its osteoblast- and osteoclast-activity-influencing behaviour [211]. This evidence concerns the gene CAVIN1 and Familial prostate cancer.