TGFB1 and cancer: Today, we know bone is a particularly attractive milieu for cancer cells: the bone matrix contains an abundance of growth factors of the transforming growth factor (TGF)-β superfamily, insulin-like growth factors (IGFs), bone morphogenetic proteins (BMPs), platelet-derived growth factor (PDGF), fibroblast growth factors (FGFs) and calcium (Ca2+) [59].