RNASE1 and fetal growth restriction: Several genes known to be critical in pathways modulating islet function gained de novo bivalency in 10-wk IUGR islets, such as Ang2, Grm7, and Nr0b2. Angiogenin, ribonuclease A family, member 2 (Ang2) is a potent mediator for new blood vessel formation [111].