Additional binding motifs that were enriched with H3K4me3 in IUGR islets include FoxL2, ETS like 1 (Elk1), ETS proto-oncogene 1 (Ets1), ETS variant 1 (Etv1), neurofibromin 1 (Nf1), and hepatocyte nuclear factor 1homeobox B (Hnf1b) (Figure 4a), which was consistent with upregulation of their target genes which we previously demonstrated [9]. This evidence concerns the gene NF1 and fetal growth restriction.