Ebf1, Sox9, Mitf, Oct4-Sox2-TCD-Nanog, and Pit1 binding motifs in 10-wk IUGR islets were enriched with H3K27me3 modifications, however, Myb and Thrb binding motifs lost their H3K27me3 marks in IUGR islets. Here, SOX2 is linked to fetal growth restriction.