To conclude, the meta-analysis finds a consistent relationship between aPL and AHIA (IgM aCL > IgG aCL > LA > IgG aβ2GPI) as well as between AIHA and thrombosis, particularly in patients with SLE: while plausible thrombogenic pathways linking AIHA and SLE do exist, the intimate nature of the reaction between different aPL isotypes and erythrocyte structures remains unclear and warrants further research. Here, CD40LG is linked to systemic lupus erythematosus.