CD40LG and systemic lupus erythematosus: On the other hand, natural IgM antibodies bound to oxidized phospholipids may prevent the activation of pro-inflammatory responses of phagocytes via scavenger receptors, such as CD36, CD68, SR-PSOX; these natural antibodies may cross react with aPL as eluates from the erythrocyte of SLE patients with aPL revealed strong cardiolipin [75] and oxidated phospatidylcholine reactivity [76].