KEAP1 and hereditary pheochromocytoma-paraganglioma: It has also been reported that BAI protects rat pheochromocytoma cells against 6-hydroxydopamine-induced neurotoxicity through the activation of Keap1/NRF2/HMOX1 pathway, indicating the potential use of BAI to prevent neurodegenerative diseases such as Parkinson’s disease [82].