Considering the potent activation of NRF2-HMOX1 system, BAI or BAI-containing drugs (WO and OG) may be beneficial for the treatment of various immunoinflammatory and autoimmune diseases in which the manipulation of NRF2-HMOX1 antioxidative system is one of the potential therapeutic approaches [76,77,78,79,80]. Here, NFE2L2 is linked to autoimmune disease.