ACHE and neurodegenerative disease: Regarding photoelectrochemical sensors, since Pardo-Yissar et al. demonstrated that AChE could be combined with semiconductor QDs for photoelectrochemical biosensing of an enzyme inhibitor [60], many biosensors using new photoactive hybrid materials have been reported for the detection of organophosphate pesticides (OPs) [20,35,61], aflatoxin B1 [62], and for AChE activity studies linked to the investigation of neurodegenerative diseases [63,64,65].