To this end, surfactin was shown to exert an anti-cancer potency against colon cancer (LoVo) cells by inhibiting their proliferation through mediation of pro-apoptotic activities and cell cycle arrest via suppression of extracellular signal-regulated kinases (ERK) and phosphatidyl inositol-3 kinase (PI3K)/v-akt murine thymoma viral oncogene homologue: protein kinase B (AKT) cell-survival signaling pathways [96]. This evidence concerns the gene AKT1 and malignant colon neoplasm.