Thus, at least part of the nephroprotective effect of BMP7 administration in diverse models of kidney fibrosis, including streptozotocin-induced DKD, was mediated by restoring TET3 mRNA expression and protein levels suppressed by TGF-β1, resulting in TET3-mediated restoration of the expression of the antifibrotic gene Rasal1. In this regard, aberrant Rasal1 methylation and hydroxymethylation were corrected by BMP7 [82] which is a nephroprotective compound for different models of CKD, including diabetic nephropathy (DN) [83]. Here, TET3 is linked to chronic kidney disease.