In two rodents models of type 1 diabetes, OVE26 mice and streptozotocin rats, the levels of H3K27m3, a repressive histone methylation mark, are reduced in key genes as Mcp-1, vimentin and the fibrosis marker Fsp1, while the levels of H3K4m2, an activating mark, are increased, suggesting that aberrant histone methylation may underlie differential kidney gene expression in DKD [97]. Here, CCL2 is linked to diabetic kidney disease.