Prior to more extensive analysis of the specific interactions of these compounds with the AhR, we first confirmed that 1,2-NQ and 1,4-NQ stimulated induction of the AhR-responsive gene CYP1A1/cyp1a1 in human and mouse hepatoma cells, respectively, in a concentration-dependent manner (Figure 2). The gene discussed is CYP1A1; the disease is hepatocellular carcinoma.